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KMID : 1100220100090030088
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Dementia and Neurocognitive Disorders
2010 Volume.9 No. 3 p.88 ~ p.92
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Analysis of Circulating CD34-positive Cells in Alzheimer’s Disease
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Lee Soon-Tae
Chu Kon
Jung Keun-Hwa
Shim Ji-Young
Oh Min-Jeong
Park Myoung-Hee
Kim Man-Ho
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Abstract
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Background: Circulating CD34-positive cells constitute the endothelial progenitor cell population, differentiate into endothelial cells, and contribute to mammalian brain regeneration. Given the vascular endothelial pathogenesis of Alzheimer’s disease (AD), we investigated the levels of CD34+ cells in AD patients.
Methods: Sixty-six consecutive patients with probable AD (clinical dementia rating scale 1) and 22 age-matched control subjects were enrolled. CD34+ cells were counted in their peripheral blood samples and analyzed in comparison with their clinical characteristics.
Results: The AD patients had significantly lower numbers of CD34-positive cells than control subjects. However, the number of CD34-positive cells was not correlated with clinical characteristics of AD patients, including Mini Mental State Examination (MMSE) score, Framingham risk score, body-mass index, and changes in MMSE during 3 months.
Conclusions: AD patients have diminished circulating CD34-positive cells, suggesting the reduced regenerative support from the peripheral blood in AD patients.
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KEYWORD
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Alzheimer’s disease, CD34, Endothelial progenitor cells, Biomarker, Mini-mental
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